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AMPHOTERICIN-B is an antifungal antibiotic. It acts by binding to ergosterol in the fungal cell membrane. The membrane of the fungal cell is altered, cellular macromolecules and ions are lost,
producing irreversible damage.
AMPHOTERICIN-B is poorly absorbed from the gastrointestinal tract. The intravenous injection of 0.5 mg/kg/day of AMPHOTERICIN-B results in average blood levels of 0.5 - 2 μg/ml. It is more than 90% protein-bound and is removed to a very limited extent by hemodialysis. The injected AMPHOTERICIN-B is excreted slowly in the urine over a period of several days. The drug is widely distributed in tissue, but only 2 - 3% of the blood level is reached in cerebrospinal fluid.
